A long time History of Research

Although probiotics have only recently become a popular topic with the public, at Morinaga we have been researching them for over 40 years!

Here is a timeline of significant events in the research of Bifidobacterium longum BB536:

Timeline of Bifidobacterium longum BB536 Research


BB536 first isolates from healthy infant


Morinaga milk supplements with BB536 available for retail sale


Research demonstrates improvement in regularity and fecal microflora of elderly subjects

Read More


Morinaga yogurt product with BB536 launches for retail sale


Morinaga receives award from the Japanese Science & Technology Agency for tge "Application of BB536 to dairy products"


Licensed production Morinaga Bifidus Yogurt begins in France and receives award from French Ministry of Agriculture


Study investigates effects of BB536 on leukemia patients (Effects of BB536 on Candida infection)

Read More


Research investigates the effects of BB536 on development of bifidobacteria flora in premature infants

Read More


Morinaga BB536 Yogurt is awarded by the Japanese Ministry of Health with FOSHU status (Food for Special Health Use)


Morinaga research shows relationship between BB536 and improvement of microflora balance and regularity (Gastrointestinal Health - GI)

Read More


BB536 is applied to constipation case; continuous research of BB536's effects if Gi health

Read More


Research investigates effects of BB536 on survival rates of mice infected with E. coli O157

Read More


Bifidobacterium longum BB536 is awarded GRAS status by the FDA


JSBBA Award for Achievement in Technological Research


More than 100 articles published for BB536


Study# 4: The effect of Bifidobacterium cultured milk on the "Regularity" among on aged group

< Publication; Journal of Japanese Society of Nutrition and Food Science 31(4) : 379-387 (1978) >


Study# 6: Intestinal Candida overgrowth and Candida infection in patients with leukemia : Effect of Bifidobacterium administration.

< Publicatoin; Bifidobacteria Microflora 7(2) : 71-74 (1988) >


Study #12: Akiyama K, et al., Effects of Administration of Bifidobacterium in extremely premature infants: Development of intestinal microflora by orally administered Bifidobacterium longum (in comparison with Bifidobacterium breve)

< Publication: Acta Neonatologica Japonica 30, 257-263. (1994) >


Study# 1: Effect of Bifidobacterium longum BB536 administration on the intestinal environment, defecation frequency and fecal characteristics of human volunteers

< Publication; Bioscience Microflora 16(2) : 53-58 (1997) > 

Study # 2: Effect of yogurt containing Bifidobacterium longum BB536 on the intestinal environment, fecal characteristics and defecation frequency: A comparison with standard yogurt

< Publication; Bioscience Microflora 16(2) : 73-77 (1997) >


Study# 35: Effect of non-fermented milk containing Bifidobacterium longum BB536 on the defecation frequency and fecal characteristics in healthy adults

< Publication; Journal of Nutritional Food 4(2) : 1-6 (2001) >

View investigations of Bifidobacterium longum BB536 (Clinical Study)


Study #36: Namba K, et al., Inhibitory effects of Bifidobacterium longum on enterohemorrhagic Escherichia coli O157:H7

< Publication: Bioscience Microflora 22 (3): 85-91 (2003) >